Significance of expressions of connexin 43 and E-cadherin in invasive ductal carcinoma

doi:10.3877/cma. j. issn.1674-0807.2012.03.007

Abstract

Abstract:

Objective

To investigate the expressions of connexin 43(Cx43) and E-cadherin(E-cad) in invasive ductal carcinoma (IDC) and their clinical significance.

Method

The expressions of Cx43 and E-cad proteins were detected in 41 cases of breast invasive ductal carcinoma,42 cases of benign breast diseases and 17 cases of normal breast tissues by immunohistochemical Elivision method. Chi-square test, McNemar test and Kappa test were used for statistical analysis.

Results

The expressions of Cx43 and E-cad were remarkably decreased in IDC tissues. Both Cx43 and E-cad expressions were significantly related with TNM stage, histologic grading and lymphatic metastasis in breast IDC(P<0.050).There was better agreement between Cx43 and E-cad expressions (Kappa=0.466,P=0.003).

Conclusion

The decreased expressions of Cx43 and E-cad in IDC might play a role in carcinogenesis and development of IDC. It is conducive to judge tumor differentiation and invasion status by detecting Cx43 and E-cad together.

Key words: breast neoplasms, connexin 43, E-cadherin, immunohistochemistry

Yi-jing GAO, Zhan CHEN, Rui LI, Xiao-mei XIE, Yong-jiu TU. Significance of expressions of connexin 43 and E-cadherin in invasive ductal carcinoma[J]. Chinese Journal of Breast Disease(Electronic Edition), 2012, 06(03): 279-286.

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References 16

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分组	例数	Cx43				E-cad
分组	例数	阳性(例)	阴性(例)	χ ²值	P值	阳性(例)	阴性(例)	χ ²值	P值
正常乳腺	17	17	0			17	0
良性病变	42	42	0	40.588	＜0.001	42	0	33.755	＜0.001
浸润性导管癌	41	19	22			22	22

分组	例数	Cx43				E-cad
分组	例数	阳性(例)	阴性(例)	χ ²值	P值	阳性(例)	阴性(例)	χ ²值	P值
正常乳腺	17	17	0			17	0
良性病变	42	42	0	40.588	＜0.001	42	0	33.755	＜0.001
浸润性导管癌	41	19	22			22	22

分组	例数	Cx43					E-cad
分组	例数	阳性(例)	阴性(例)	阳性率(%)	χ ²	P值	阳性(例)	阴性(例)	阳性率(%)	χ ²	P值
淋巴结转移					9.616	0.001				6.866	0.008
转移组	17	3	14	17.60%			5	12	29.40%
未转移组	24	16	8	66.70%			17	7	70.80%
TNM分期					8.785	＜0.01				5.381	0.020
Ⅰ+Ⅱ	27	17	10	63.00%			18	9	66.70%
Ⅲ+Ⅳ	14	2	12	14.30%			4	10	28.60%
组织学分组					9.336	＜0.01				9.856	0.001
Ⅰ+Ⅱ	12	10	2	83.30%			11	1	91.67%
Ⅲ	29	9	20	31.00%			11	18	37.90%

分组	例数	Cx43					E-cad
分组	例数	阳性(例)	阴性(例)	阳性率(%)	χ ²	P值	阳性(例)	阴性(例)	阳性率(%)	χ ²	P值
淋巴结转移					9.616	0.001				6.866	0.008
转移组	17	3	14	17.60%			5	12	29.40%
未转移组	24	16	8	66.70%			17	7	70.80%
TNM分期					8.785	＜0.01				5.381	0.020
Ⅰ+Ⅱ	27	17	10	63.00%			18	9	66.70%
Ⅲ+Ⅳ	14	2	12	14.30%			4	10	28.60%
组织学分组					9.336	＜0.01				9.856	0.001
Ⅰ+Ⅱ	12	10	2	83.30%			11	1	91.67%
Ⅲ	29	9	20	31.00%			11	18	37.90%

Cx43	E-cad(例)		P值^a
Cx43	+	-	P值^a
+	15	4	0.549
-	7	15	0.549

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